I've played in windowed since I've started playing, and I notice that I still miss quite a bit of some free last hits. However, most players play in Full-Screen. So it easier or the same? I'd say it's easier to last hit in Full-Screen just because there are more details and it's easier...but I want to get some intake on this.
The difference is so negligable I highly doubt you'd notice a difference. Why would you play in windowed mode anyway?
Despite what they would have you believe, HoN forum-goers are indeed just a vocal minority, <1700 mmr and more susceptible to confirmation bias than most normal human beings...
MIA=Missing in Action.
HoN is not DotA; and one extra key-press won't kill you
Windowed mode will give you lower FPS, that could be why.
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