I've played in windowed since I've started playing, and I notice that I still miss quite a bit of some free last hits. However, most players play in Full-Screen. So it easier or the same? I'd say it's easier to last hit in Full-Screen just because there are more details and it's easier...but I want to get some intake on this.
The difference is so negligable I highly doubt you'd notice a difference. Why would you play in windowed mode anyway?
Despite what they would have you believe, HoN forum-goers are indeed just a vocal minority, <1700 mmr and more susceptible to confirmation bias than most normal human beings...
MIA=Missing in Action.
HoN is not DotA; and one extra key-press won't kill you
Windowed mode will give you lower FPS, that could be why.
Game Masters are not S2 Games employees. My posts in no way represent the view of S2 Games or any of its staff.