Ever since the patch to 22.214.171.124 the random distorting of graphics came back (this happened in a previous patch but it then fixed itself. I don't remember the patch but I believe it was a major one about 6 patches or so back?).
In addition to distortion of graphics in-game, it's now effecting my overall desktop. I'm getting pixelated boxes and what not. The only way I've found to solve this is to reboot. I've ran tests to see if the card is overheating, I've cleaned the fans, even ran the computer for extended period of time with and without the game running, and furthermore I've played other (more graphic demanding) games to see if I get the same result...nothing. Also note, that I've ran the MSI Afterburner (with Kombuster) and can't get any distortion.
I've isolated this to HoN.
Memory: 6 GB
OS: Windows 7 Home Premium 64-bit
CPU: Intel Core i7 CPU 870 @ ~2.9GHz
Video Card: NVIDIA GeForce GTX 560 Ti